氯化铁（III）六水合物可作为催化剂用于：
脂肪酸和醇的酯化合成脂肪酸酯。
通过Friedel-Crafts烷基化反应使 α-氨基砜和富电子的芳烃区域选择性芳基化合成不对成或双对称三芳基甲烷。
通过叠氮化钠和 N-酰基苯并三唑酰化反应合成酰基叠氮衍生物。

Iron(III)chloride hexahydrate can be used as a catalyst for the:
Esterification of fatty acids and alcohols to synthesize fatty acid esters.
Regioselective arylations of α-amido sulfones with electron-rich arenes to synthesize unsymmetrical or bis-symmetrical triarylmethanes via Friedel-Crafts alkylation.
Synthesis of acyl azide derivatives by the acylation of sodium azide with N-acylbenzotriazoles.